Lexocytes had shown up fairly early in the human research on Crab biology, and it's now clear that the probe itself had initiated a line of inquiry that would have discovered them in short order as well. Lexocytes are fundamental to the Crab life cycle, development, evolution and society. One cannot understand Crabs without understanding the role of Lexocytes.
It's well known that microbes can alter behavior, even human behavior. The feline protozoan parasite Toxoplasma gondii has an affinity not just for cats but for any warm-blooded mammal. In mice and rats it reduces fear of cats -- and only cats -- the more the parasite can re-infect its primary host. Human infections exhibit a sexual dimension, making women more outgoing and promiscuous and men more aggressive and jealous. One can only wonder what this says about how the relationship between humans and their feline pets has affected parasite evolution.
Lexocytes ceased being parasites millions of years ago and instead established a symbiotic union with Crabs of unprecedented intimacy. The team on the E.O.Wilson painstakingly broke it down to its simplest details. Lexocytes live mostly in Crab brain tissue. Crab neurology is complicated, but the role of the Lexocytes can be explained in relatively simple terms. Each Lexocyte cell sits at the junction of Crab neurons, mediating the signaling between them. Sometimes a signal will come to the synapse and the Lexocyte will do nothing, letting the signal pass. Other times a signal will come in and the Lexocyte will throw up a chemical smokescreen to block it.
But how does the tiny microbe know which signals to allow and which to block? Fortunately this was a technology with which humans are well-versed -- genetics. Lexocytes contain a huge amount of kDNA. Some of it is used for normal purposes, like keeping the cell alive, but the rest operates quite differently. Instead of being transcribed into proteins like ordinary genetic sequences, these are converted into what were named "tapes". Tapes bind with enzymes called "read heads". Excitation from the giant neuron triggers the read head to move ahead one step on the tape. The "symbol" -- like a codon in Earthly genetics -- can represent one of six possible states, and the read head enzyme either emits a hydroxide ion or doesn't depending on the state. Ultimately it's the pH of the cell from the tens of thousands of simultaneous read heads ticking over that determines if the signal is inhibited or not.
When a signal comes in, all the read heads advance a symbol on the tape and cast their vote. Majority rules.
But what decides which tapes to run? The Lexocyte genome is enormous, dwarfing the genetic sequence of their Crab hosts. That mechanism is also very simple. The pattern of accept/reject answers that the read-head enzymes generate alters their chemical structure. As they release hydroxide ions a structure called the "hydroxyl tail" can change to take on up to 12 different configurations. As the tape completes it is released by the read head, but not before it binds with the tail. The tail and the tape form a new complex, and that -- by decoration with potassium and a set of other markers -- has a role in determining which tapes among the millions possible will be selected next.
As each tape's term expires, it elects it's successor.
In general, in fact, most tapes elect themselves. The tail only has 12 states so there are very few possible outcomes given the accessible pool of tapes. The other common outcome is a pair of tapes, with tape A electing tape B and B electing A. Biologists called this a "nepotistic mobius," although it seems very familiar to anyone who understands politics. But these are just molecules, so we shouldn't imbue them with any motives beyond replication of their genotype.
Tapes may run over and over again for hundreds of cycles, but eventually they change. The outcomes start to become unfavorable for the current population of tapes and new tapes start to be selected. Eventually they bring in all of their related tapes and a new population dominates, at least for a few milliseconds. They then give way to a new population and so forth. Typically one population is stable for a while until there is a shift, and then populations change one after another in quick succession until a new equilibrium is reached.
But what's the point of all of this detailed biochemistry? This is just organic molecules doing what they do based on nothing but eons-old genetic programming. And yet, this simple biochemical churning is why the Crabs are different from their closest ancestor. The latter scavenges the shoreline for trash, the former builds spaceships. It behooves us to understand the difference.
After all -- that's all we are too. The difference between us and chimps is some small biochemical activity that can be described in no less simple terms. Sometimes it seems like we understand Crabs better.